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. 1971 Feb;105(2):666-72.
doi: 10.1128/jb.105.2.666-672.1971.

Deoxycytidine triphosphate deaminase: characterization of an Escherichia coli mutant deficient in the enzyme

G A O'Donovan, G Edlin, J A Fuchs, J Neuhard, E Thomassen

Deoxycytidine triphosphate deaminase: characterization of an Escherichia coli mutant deficient in the enzyme

G A O'Donovan et al. J Bacteriol. 1971 Feb.

Abstract

A mutant of Escherichia coli, previously shown to contain abnormal nucleoside triphosphate pools, was found to be defective in its ability to synthesize thymidine nucleotides. The defect is not in the enzyme thymidylate synthetase but in deoxycytidine triphosphate deaminase, an enzyme that supplies deoxyuridine monophosphate, the substrate for thymidylate synthetase.

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References

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