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. 1971 Mar 12;171(3975):1024-6.
doi: 10.1126/science.171.3975.1024.

Scanning electron microscopic observations of surface structure of isolated human chromosomes

H M Golomb, G F Bahr

Scanning electron microscopic observations of surface structure of isolated human chromosomes

H M Golomb et al. Science. .

Abstract

Isolated human chromosomes dried by the critical-point method have been assumed to retain their original three-dimensional shape when viewed under a transmission electron microscope. Our scanning electron microscopic study confirms this interpretation and reveals an appearance like that of a skein of yarn. The existence of fiber bridges between chromatid pairs and among chromosomes is demonstrated.

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