Sensory cells in the spinal cord of the sea lamprey

Abstract

1. Intracellular recordings were made from dorsal cells in the spinal cord of the sea lamprey.2. Dorsal cells were excited by mechanical stimulation of the ipsilateral skin and were established as first-order sensory cells using a variety of physiological criteria. Receptive fields were mapped.3. Dorsal cells were subdivided into three functional types on the basis of their responses to mechanical stimulation of the skin. Touch (T) cells gave rapidly adapting responses to indentation of the skin. Pressure (P) cells gave slowly adapting responses to indentation of the skin. Nociceptive (N) cells gave slowly adapting responses to severe (often destructive) indentation of the skin. The three types also differed in their spontaneous activity and in their response to repeated stimulation.4. Pressure and nociceptive cells were excited by heating the skin over the receptive field. The amount of heat necessary to excite nociceptive cells was greater than that necessary for pressure cells and often left a permanent burn mark on the skin.5. The three types of dorsal cell also showed differences in resting potential, membrane time constant, spike threshold, and response to sustained depolarization.