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. 1971 Apr 9;172(3979):162-3.
doi: 10.1126/science.172.3979.162.

New class of purine mutants of Chinese hamster ovary cells

M W Taylor, M Souhrada, J McCall

New class of purine mutants of Chinese hamster ovary cells

M W Taylor et al. Science. .

Abstract

Mutants of Chinese hamster ovary cells (CHO/Pro(-)) were isolated after mutagenesis with N-methylnitrosoguanidine and selection by the bromodeoxyuridine technique. Six of these were mutants classified as purine-requiring. The metabolic block appears to be early in the purine biosynthetic pathway. The mutants do not appear to be genetically identical.

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