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. 1971 Apr 9;172(3979):165-7.
doi: 10.1126/science.172.3979.165.

Activity of delta8- and delta9-tetrahydrocannabinol and related compounds in the mouse

H D Christensen, R I Freudenthal, J T Gidley, R Rosenfeld, G Boegli, L Testino, D R Brine, C G Pitt, M E Wall

Activity of delta8- and delta9-tetrahydrocannabinol and related compounds in the mouse

H D Christensen et al. Science. .

Abstract

The 11-hydroxy metabolites of Delta(8).- and Delta(9)-tetrahydrocannabinol are more active than the parent compounds when administered to mice by either the intravenous or intracerebral route. Both Delta(8)- and Delta(9)-tetrahydrocannabinol are rapidly and extensively metabolized by the liver and not by the brain. The hypothesis that the 11-hydroxy metabolites may be the active form of tetrahydrocannabinol is discussed

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