doi: 10.1126/science.172.3980.281.
Norepinephrine: reversal of anorexia in rats with lateral hypothalamic damage
- PMID: 5548711
- DOI: 10.1126/science.172.3980.281
Item in Clipboard
Norepinephrine: reversal of anorexia in rats with lateral hypothalamic damage
Science.
.
Abstract
Injection of norepinephrine in the lateral ventricles of rats recovering from lateral hypothalamic anorexia caused immediate feeding and, frequently, overeating. Intraventricular administration of the alpha-noradrenergic blocker, phentolamine, suppressed feeding in both normal rats and rats that had recovered from lateral hypothalamic lesions. Feeding is reinforced by ascending medial forebrain bundle fibers that form alpha-noradrenergic synapses in the hypothalamus and forebrain. Damage to these fibers suppresses feeding by reducing noradrenergic transmission and, hence, the rewarding value of food. Recovery of feeding after hypothalamic lesions coincides with the recovery of noradrenergic reward function.
Similar articles
-
Catecholaminergic mechanisms of the lateral hypothalamus: their role in the mediation of amphetamine anorexia.Brain Res. 1975 Nov 21;98(3):529-45. doi: 10.1016/0006-8993(75)90371-6. Brain Res. 1975. PMID: 1182535
-
[Role of the adrenergic system in lateral hypothalamic self stimulation behavior: effects induced by intraventricular injection of epinephrine, norepinephrine, isoproterenol and dopamine].Nihon Yakurigaku Zasshi. 1976 Nov;72(8):979-84. Nihon Yakurigaku Zasshi. 1976. PMID: 1035565 Japanese.
-
Effects of lesions of various medial forebrain bundle components on lateral hypothalamic self-stimulation.Brain Res. 1977 Sep 9;133(1):45-63. doi: 10.1016/0006-8993(77)90048-8. Brain Res. 1977. PMID: 302729
-
Microdialysis studies of brain norepinephrine, serotonin, and dopamine release during ingestive behavior. Theoretical and clinical implications.Ann N Y Acad Sci. 1989;575:171-91; discussion 192-3. doi: 10.1111/j.1749-6632.1989.tb53242.x. Ann N Y Acad Sci. 1989. PMID: 2699187 Review.
-
Brain reward and aversion systems in the control of feeding and sexual behavior.Nebr Symp Motiv. 1975;22:49-112. Nebr Symp Motiv. 1975. PMID: 1107869 Review. No abstract available.
Cited by
-
Naloxone in anorexia nervosa: role of the opiate system.J R Soc Med. 1981 Aug;74(8):631-2. doi: 10.1177/014107688107400820. J R Soc Med. 1981. PMID: 7288803 Free PMC article. No abstract available.
-
Acetazolamide increases locomotion, exploratory behavior, and weight loss following social stress: A treatment for emotional eating?.Metabol Open. 2020 Jan 13;5:100023. doi: 10.1016/j.metop.2020.100023. eCollection 2020 Mar. Metabol Open. 2020. PMID: 32812910 Free PMC article.
-
Alprazolam attenuates metabolic stress-induced neuroendocrine and behavioral effects in humans.Psychopharmacology (Berl). 1991;104(4):479-84. doi: 10.1007/BF02245653. Psychopharmacology (Berl). 1991. PMID: 1780418 Clinical Trial.
-
Reward from bugs to bipeds: a comparative approach to understanding how reward circuits function.J Neurogenet. 2016 Jun;30(2):133-48. doi: 10.1080/01677063.2016.1180385. J Neurogenet. 2016. PMID: 27328845 Free PMC article. Review.
-
The effect of bilateral ventral noradrenaline bundle lesions on lever pressing for food in rats.Psychopharmacology (Berl). 1979 Jun 28;64(1):41-3. doi: 10.1007/BF00427343. Psychopharmacology (Berl). 1979. PMID: 113830
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
