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. 1979;1(3):399-408.
doi: 10.1097/00007691-197901030-00013.

High performance liquid chromatographic analysis of hydrochlorothiazide in serum and urine

S J Soldin, E Hach, A Pollard, A G Logan

High performance liquid chromatographic analysis of hydrochlorothiazide in serum and urine

S J Soldin et al. Ther Drug Monit. 1979.

Abstract

We report a high performance liquid chromatographic method for the analysis of hydrochlorothiazide in 500microliter of serum of 25 microliter of urine. The between-day precision of the analysis (CV 5.0-7.0%) is acceptable, as is the recovery of hydrochlorothiazide (90-96%) and trichloromethiazide (96%) added to serum. No drug or drug metabolite interferences have been noted. The method represents a considerable improvement over existing techniques described in the literature.

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