Pharmacokinetics of Carbamazepine in man: a review

Abstract

Gas-liquid chromatographic methods for determining plasma concentrations of the anticonvulsant drug carbamazepine are described. The pharmacokinetics of carbamazepine (absorption, protein binding, distribution, metabolism, and elimination) are reviewed, as well as the relationship between dose and plasma level and between plasma level and drug effects. Interactions with other drugs are noted.