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. 1971 Aug 6;173(3996):542-4.
doi: 10.1126/science.173.3996.542.

Human lymphocyte antigen reactivity modified by neuraminidase

E A Grothaus, M W Flye, E Yunis, D B Amos

Human lymphocyte antigen reactivity modified by neuraminidase

E A Grothaus et al. Science. .

Abstract

Human lymphocytes treated with neuraminidase (from Vibrio cholera) are more susceptible to lysis with antiserums directed against HL-A antigens in the cytotoxicity test than are the corresponding cells incubated in buffer. Enzymetreated cells are also lysed by antibodies other than those directed against HL-A, but control cells are not. The extra sensitivity to antibody disappears after 2 to 6 days in tissue culture.

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