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Clinical Trial
. 1977 Jan;27(1):70-2.
doi: 10.1212/wnl.27.1.70.

Physostigmine in familial ataxias

Clinical Trial

Physostigmine in familial ataxias

R A Kark et al. Neurology. 1977 Jan.

Abstract

Physostigmine was given to 12 patients with various spincerebellar degenerations, and neurologic examinations were recorded on video tapes and assessed on a semiquantitative scale. Forty minutes after a single dose, the scores improved by 35.7 +/- 4.7 percent (means +/- SEM). Eight patients were then studied over sequential 3-month periods by a randomized double-blind trial of physostigmine versus placebo. With physostigmine, scores were 33.9 +/- 8.3 percent better than before treatment or with placebo. Further investigations of cholinergic drugs seem warranted in patients with these diseases.

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