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. 1971 May 1;2(5756):258-60.
doi: 10.1136/bmj.2.5756.258.

Recovery of prostaglandins in human cutaneous inflammation

M W Greaves, J Sondergaard, W McDonald-Gibson

Recovery of prostaglandins in human cutaneous inflammation

M W Greaves et al. Br Med J. .

Abstract

An in-vivo skin perfusion technique has been used to study the pharmacological activity in inflamed skin of patients with allergic contact eczema. Perfusates from 35 out of 45 patients contained a smooth-muscle-contracting agent with prostaglandin-like properties. Solvent partition followed by thinlayer chromatography revealed this activity to be due to a mixture of prostaglandins E and F. This direct evidence supports the view that prostaglandins mediate inflammation in man.

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References

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