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. 1971 Apr;8(4):617-23.

In vitro lymphocyte transformation induced by pre-existing hypersensitivity to foetal calf serum

M L Howe, J R Battisto

In vitro lymphocyte transformation induced by pre-existing hypersensitivity to foetal calf serum

M L Howe et al. Clin Exp Immunol. 1971 Apr.

Abstract

Certain foetal calf sera (FCS), upon initial injection, elicit delayed dermal reactions in some but not all guinea-pigs. The FCS that evoke significant dermal responses also initiate in vitro blastogenesis of lymphocytes taken from animals exhibiting the dermal reactions. A correlation exists between the severity of the in vivo reactions and the degree of blastogenesis observed.

An explanation for these observations has been suggested, i.e. that some guinea-pigs possess spontaneously developed delayed hypersensitivity for antigen(s) contained in FCS.

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References

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