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. 1977 Mar 17;266(5599):235-9.
doi: 10.1038/266235a0.

5'-Terminal structure and mRNA stability

Y Furuichi, A LaFiandra, A J Shatkin

5'-Terminal structure and mRNA stability

Y Furuichi et al. Nature. .

Abstract

Reovirus mRNAs with 5'terminal m7GpppGm or GpppG are more stable than mRNA containing unblocked ppG 5'-ends when injected into Xenopus laevis oocytes or incubated in cell-free protein synthesising extracts of wheat germ and mouse L cells. The greater stability of mRNA with blocked 5' termini is not dependent upon translation but seems to result from protection against 5'-exonucleolytic degradation.

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