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. 1976 Mar 6;1(7958):508-9.
doi: 10.1016/s0140-6736(76)90295-6.

Terminal transferase in human bone-marrow lymphocytes

R D Barr, P S Sarin, S M Perry

Terminal transferase in human bone-marrow lymphocytes

R D Barr et al. Lancet. .

Abstract

Activity of the enzyme terminal transferase (TdT) has been localised in normal human bone-marrow lymphocytes. These cells may represent a prothymocyte population, which, on malignant transformation, may give rise to acute lymphoblastic leukaemia, and to some cases of chronic granulocytic leukaemia in the blastic phase.

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