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. 1977 Apr 19;475(4):601-4.
doi: 10.1016/0005-2787(77)90320-3.

Calorimetric measurements of the transition enthalpy of DNA in aqueous urea solutions

H Klump, W Burkart

Calorimetric measurements of the transition enthalpy of DNA in aqueous urea solutions

H Klump et al. Biochim Biophys Acta. .

Abstract

The helix-coil equilibrium of DNA is delicately affected by the nature of the solvent. In this investigation the helical secondary structure was destabilized by an increasing concentration of urea. We found a linear dependence of the transition enthalpy deltaH on the urea concentration for calf thymus DNA as well as for salmon sperm DNA.

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