[The frequency of congenital adrenal hyperplasia (cah) in Munich (author's transl)]

Abstract

In Munich the frequency of homozygotes of CAH (with and without salt losing syndrome) in the years 1963-1972 was 1; 9831. The CAH gen frequency was 1:99 and the frequency of heterozygote carriers was 1: 50. From these observations it was concluded that the number of undiagnosed boys suffering from CAH without salt losing syndrome must be very high. Assuming a sex ration of 1:1 for the children without salt losing syndrome the frequency of homozygotes (with and without salt losing syndrome) can be calculated to 1:7520. The statistical comparison of the frequency for Munich and for Zürich (Prader 1958) does not show a significant difference.