Abstract

PIP: Inbred mice were treated for 305 days with Anovlar. Throughout the observation under continuous hormonal treatment there was neither an increase in spontaneous mammary tumour rate nor any reduction in tumour taking time. Mortality was higher in the hormone-treated animals, obviously because they badly tolerated the treatment at the beginning of the experiment. If further studies do not reveal a cocarcinogenity of the hormonal preparations or show a cancriprophylactical action, they might be well recommended as anticarcinogenic drugs for women.