Transformation of BHK 21/13 cells by chemical carcinogens and mutagens
- PMID: 55982
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Transformation of BHK 21/13 cells by chemical carcinogens and mutagens
Neoplasma.
1975.
Abstract
In vitro transformation of BHK 21/13 cells by chemical carcinogens is reported. The hamster cells were treated with MCA, BP, 4-NQO and 5-azaCR at various concentration and duration of treatment. The morphological, karyological and growth characteristics of cell lines were investigated. Search for RNA tumor viruses in transformed cells using 3H-uridine labeling, detection of DNA polymerases, electron microscopy investigations failed to detect presence of C-type virus particles.
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