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. 1977 Sep 5;469(2):216-20.
doi: 10.1016/0005-2736(77)90184-5.

Does the non-saturable cell entry apply to the charge-free form of amino acids?

H N Christensen, M E Handlogten
Free article

Does the non-saturable cell entry apply to the charge-free form of amino acids?

H N Christensen et al. Biochim Biophys Acta. .
Free article

Abstract

The slow cellular entry shown by neutral alpha-amino acids at very high concentrations appears not to arise from diffusion of the totally uncharged species through the plasma membrane of the Ehrlich cell, judging from a similarity of the rates observed for the two conformational isomers of 1-amino-2-hydroxy-cyclohexane-carboxylic acid. One of these isomers provides in neutral solution 4 times as large a proportion of the charge-free species as the other, and 5 times the proportion calculated for alanine.

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