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Case Reports
. 1977 Nov;66(6):783-5.
doi: 10.1111/j.1651-2227.1977.tb07989.x.

Monozygotic twins concordant for tracheo-esophageal fistula and discordant for the VATER association

S L King, R L Ladda, S J Shochat
Case Reports

Monozygotic twins concordant for tracheo-esophageal fistula and discordant for the VATER association

S L King et al. Acta Paediatr Scand. 1977 Nov.

Abstract

Monozygotic female twins were concordant for tracheo-esophageal fistula (TEF); and one twin also manifested other anomalies in the VATER association, including agenesis of the female reproductive tract. Review of the literature discloses a familial tendency for recurrence of TEF and a high concordance rate in monozygotic twins, indicating a significant genetic influence for the isolated anomaly. In the case of the VATER association, the sporadic occurrence of affected individuals and discordance in twins implicates the effect of non-genetic factors.

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