doi: 10.1016/0014-2999(76)90316-2.
Potassium-induced release of tritiated histamine from rat brain tissue slices
- PMID: 56272
- DOI: 10.1016/0014-2999(76)90316-2
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Potassium-induced release of tritiated histamine from rat brain tissue slices
Eur J Pharmacol.
1976 Jan.
Abstract
The release of exogenous histamine was studied by superfusing brain slices following incubation with the radiolabeled amine. Histamine was released in a calcium-dependent way by 40 mM potassium. This release was high in hypothalamus and striatum and low in hippocampus and cortex. Compound 48/80, a mast cell histamine releasing agent, also induced histamine release, but only from hypothalamic tissue slices. It is suggested that the potassium-induced release of accumulated exogenous histamine is mainly from glial cells.
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