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. 1977 Oct 1;45(3):291-4.
doi: 10.1016/0014-2999(77)90012-7.

Rotational behavior induced in rats by intranigral application of GABA-related drugs and GABA antagonists

H R Olpe, H Schellenberg, W P Koella

Rotational behavior induced in rats by intranigral application of GABA-related drugs and GABA antagonists

H R Olpe et al. Eur J Pharmacol. .

Abstract

GABA and GABA-related drugs such as muscimol, gamma-hydroxybutyric acid and baclofen injected unilaterally into the substantia nigra of rats elicited contraversive turning. Unilateral injections of picrotoxin and bicuculline produced either ipsi- or contraversive turning depending on the volume of vehicle. I.p. applied haloperidol did not abolish the muscimol-induced turning. This and the direction of rotational behavior suggests that the turning behavior elicited by GABA-related drugs is not mediated by the nigrostriatal dopaminergic tract.

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