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. 1977 Sep-Oct;40(5):479-81.

Aplysinopsin: antineoplastic tryptophan derivative from the marine sponge Verongia spengelii

K H Hollenbeak, F J Schmitz
  • PMID: 562965

Aplysinopsin: antineoplastic tryptophan derivative from the marine sponge Verongia spengelii

K H Hollenbeak et al. Lloydia. 1977 Sep-Oct.

Abstract

Bioassay-guided fractionation of the aqueous alcoholic extract of the marine sponge Verongia spengelii for tumor inhibitory agents led to the isolation of aplysinopsin, a new tryptophan derivative recently reported from another sponge Thorecta aplysinopsis. Aplysinopsin showed cytotoxicity against the KB, P388 and L1210 cell cultures.

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