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Comparative Study
. 1977 Sep-Oct;27(5):1030-5.

[Effect of destruction of midbrain raphe nuclei on the behavioral effects of dopaminergic substances and I-tryptophan]

[Article in Russian]
L Kh Allikmets, A M Zharkovskiĭ, A G Arro
  • PMID: 563144
Comparative Study

[Effect of destruction of midbrain raphe nuclei on the behavioral effects of dopaminergic substances and I-tryptophan]

[Article in Russian]
L Kh Allikmets et al. Zh Vyssh Nerv Deiat Im I P Pavlova. 1977 Sep-Oct.

Abstract

In experiments on male albino rats, after electrolytic lesions of dorsal and median mesencephalic raphe nuclei, l-DOPA and apomorphine did not exert their stimulating effect on aggressiveness and emotional reactivity, seen in control false-operated animals. The inhibitory effect of haloperidol on emotional reactivity increased after raphectomy. The stereotype behaviour elicited by dopaminergic agents and their effects on exploratory motor activity were not changed by raphectomy. It is assumed that the effects of dopamino-potentiating agents on emotional reactivity are partly mediated by their influence on serotonergic system.

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