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. 1978 Jan 26;271(5643):329-33.
doi: 10.1038/271329a0.

X-chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitro

G R Martin, C J Epstein, B Travis, G Tucker, S Yatziv, D W Martin Jr, S Clift, S Cohen

X-chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitro

G R Martin et al. Nature. .

Abstract

Evidence is presented that both X chromosomes are genetically active in clonal cultures of undifferentiated female mouse teratocarcinoma stem cells derived from a spontaneous ovarian tumour. As the cells differentiate in vitro one of the X chromosomes becomes inactivated.

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