Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1968 Feb;106(3):623-6.
doi: 10.1042/bj1060623.

The introduction of the C-22-C-23 ethylenic linkage in ergosterol biosynthesis

M Akhtar, M A Parvez, P F Hunt

The introduction of the C-22-C-23 ethylenic linkage in ergosterol biosynthesis

M Akhtar et al. Biochem J. 1968 Feb.

Abstract

Methods for the chemical synthesis of [23-(3)H(2)]lanosterol, [23,25-(3)H(3)]24-methyldihydrolanosterol and [24,28-(3)H(2)]24-methyldihydrolanosterol are described. It is shown that, in the biosynthesis of ergosterol from [26,27-(14)C(2),23-(3)H(2)]lanosterol by the whole cells of Saccharomyces cerevisiae, one of the original C-23 hydrogen atoms is lost and the other is retained at C-23 of ergosterol. It is also shown that 24-methyldihydrolanosterol is converted into ergosterol in good yield and without prior conversion into a 24-methylene derivative. On the basis of these results possible pathways for the formation of the ergosterol side chain from a 24-methylene side chain are discussed.

PubMed Disclaimer

References

    1. Biochem J. 1967 Jun;103(3):616-22 - PubMed
    1. J Biol Chem. 1967 Jan 25;242(2):222-7 - PubMed
    1. Biochem J. 1967 Jul;104(1):43-56 - PubMed
    1. Biochem J. 1967 Dec;105(3):1187-94 - PubMed
    1. Biochem J. 1967 Feb;102(2):462-7 - PubMed