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. 1968 Apr;8(4):490-9.
doi: 10.1016/S0006-3495(68)86502-6.

Pyrimidine dimers in the DNA of Paramecium aurelia

B M Sutherland, W L Carrier, R B Setlow

Pyrimidine dimers in the DNA of Paramecium aurelia

B M Sutherland et al. Biophys J. 1968 Apr.

Abstract

The production and fate of thymine-containing pyrimidine dimers in Paramecium aurelia DNA was investigated in three experimental series: production of dimers by UV irradiation, fate of dimers in the dark, and "loss of photoreactivability of dimers." It is shown that cyclobutyl dimers are made by UV irradiation of Paramecium DNA in vivo, that because of cytoplasmic absorption the number of dimers made in DNA irradiated in vivo is much lower than in DNA irradiated in vitro, that dimers are lost from animals incubated in the dark after irradiation, and that all the dimers that remain in the animals can be destroyed by photoreactivating illumination. Since mutation induction is photoreactivable, these and previous photoreactivation data suggest that pyrimidine dimers are important in mutation induction in P. aurelia.

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