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Comparative Study
. 1978 Jan-Feb;57(1):25-7.
doi: 10.1213/00000539-197801000-00005.

Procaine, lidocaine, and ketamine inhibit histamine-induced contracture of guinea pig tracheal muscle in vitro

H T Wanna, S D Gergis
Comparative Study

Procaine, lidocaine, and ketamine inhibit histamine-induced contracture of guinea pig tracheal muscle in vitro

H T Wanna et al. Anesth Analg. 1978 Jan-Feb.

Abstract

In vitro experiments using guinea pig tracheal smooth muscle were performed to compare the relaxant properties of procaine, lidocaine, and ketamine following contracture induced by histamine. Procaine produced a spasmolytic effect in a dose-related manner. In the doses tested, relaxation induced by procaine was more pronounced than that produced by either lidocaine or ketamine, although the latter 2 drugs also had a significant spasmolytic effect.

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