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. 1968 May 1;127(5):853-66.
doi: 10.1084/jem.127.5.853.

Induction of bone marrow colony-stimulating activity by a filterable agent in leukemic and normal mouse serum

R Foster Jr, D Metcalf, R Kirchmyer

Induction of bone marrow colony-stimulating activity by a filterable agent in leukemic and normal mouse serum

R Foster Jr et al. J Exp Med. .

Abstract

1. Leukemic Swiss mice of ICR/Ha strain which had been injected at birth with a lymphoid-leukemia-inducing virus preparation yielded sera which produced elevations of serum colony-stimulating activity within 16 hr and significant plasma-LDH-enzyme elevation at 4 days when injected intraperitoneally into normal ICR/Ha Swiss mice. Colony-stimulating activity was assayed in vitro by the stimulation of hemopoietic colony formation by DBA/1 bone marrow cells. 2. The inducing agent in leukemic serum was passageable, filterable, sedimentable, and heat-, ether-, and UV-labile. 3. A similar agent was recovered from normal Swiss serum after blind serial passages through normal mice. 4. LDH elevating virus induced a similar elevation of serum colony-stimulating activity when injected at high titers, and cross-resistance was demonstrated between LDH virus and the passaged leukemic serum agent.

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