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. 1968 May 1;127(5):915-26.
doi: 10.1084/jem.127.5.915.

Persistence of immunogenicity of antigen after uptake by macrophages

E R Unanue, B A Askonas

Persistence of immunogenicity of antigen after uptake by macrophages

E R Unanue et al. J Exp Med. .

Abstract

Peritoneal macrophages were cultured for several hours after uptake of (131)I-hemocyanin. The cells degraded most of the (131)I-labeled protein within 2-5 hr. Their ability to prime lymphocytes of syngeneic mice for a secondary immune challenge remained unchanged for long periods of time despite the loss of more than 90% of the original content of antigen. The persistence of immunogenicity was associated with a small percentage of antigen retained by the cell in a form which was protected from rapid breakdown and elimination.

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