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. 1968 Jul 19;161(3838):280-1.
doi: 10.1126/science.161.3838.280.

4-Leucine-oxytocin: natriuretic, diuretic, and antivasopressin polypeptide

W Y Chan, V J Hruby, G Flouret, V Du Vigneuad

4-Leucine-oxytocin: natriuretic, diuretic, and antivasopressin polypeptide

W Y Chan et al. Science. .

Abstract

During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucine-oxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to freewater clearance.

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