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Clinical Trial
. 1976 Apr 10;1(7963):772-4.
doi: 10.1016/s0140-6736(76)91611-1.

Inhibition of frusemide-induced hyperreninaemia by growth-hormone release-inhibiting hormone in man

Clinical Trial

Inhibition of frusemide-induced hyperreninaemia by growth-hormone release-inhibiting hormone in man

J Rosenthal et al. Lancet. .

Abstract

In a study of the effect of somatostatin (growth-hormone release-inhibiting hormone) on plasma-renin in healthy volunteers, plasma-renin activity was measured by radioimmunoassay after the intravenous administration of somatostatin and also during frusemide-induced hyperreninaemia. While somatostatin was being given, basal values of renin were unchanged. Injection of frusemide alone produced hyperreninaemia; but, under somatostatin, renin release was inhibited by 45%. The results indicate that somatostatin is a potent inhibitor of renin and exerts its effect independent of sodium excretion, which was unchanged under somatostatin. Conceivably, somatostatin plays an important role in the regulation of endogenous renin release.

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