doi: 10.1016/s0140-6736(76)91614-7.
alpha1-Macroglobulin and reduced basement-membrane degradation in diabetes
- PMID: 56592
- DOI: 10.1016/s0140-6736(76)91614-7
Item in Clipboard
alpha1-Macroglobulin and reduced basement-membrane degradation in diabetes
Lancet.
.
Abstract
Thickening of the capillary basement membrane is the fundamental morphological alteration of diabetic microangiopathy. Leucocyte neutral proteases can degrade basement membrane in vivo. The activity of a purified neutral protease from granulocytes is inhibited by alpha2-macroglobulin. It is suggested that the reported increase in the concentration of alpha 2-macroglobulin in the blood of diabetic patients inhibits the activity of leucocyte neutral proteases which normally degrade basement membrane. The resultant decreased rate of breakdown would contribute to the increase in basement-membrane material seen in diabetes.
Similar articles
-
Letter: Alpha-2 macroglobulin and reduced basement-membrane degradation in diabetes.Lancet. 1976 May 1;1(7966):963-4. doi: 10.1016/s0140-6736(76)92741-0. Lancet. 1976. PMID: 57362 No abstract available.
-
Cationic proteins of human granulocytes. V. Interaction with plasma protease inhibitors.Scand J Clin Lab Invest. 1975 Dec;35(8):737-44. doi: 10.3109/00365517509095805. Scand J Clin Lab Invest. 1975. PMID: 54932
-
Basement-membrane thickening and diabetic microangiopathy.Diabetes. 1976;25(2 SUPPL):925-7. Diabetes. 1976. PMID: 786763 Review.
-
[Alpha2-macroglobulin in diabetic disease and in its microangiopathic complications].Minerva Med. 1983 Oct 13;74(39):2287-9. Minerva Med. 1983. PMID: 6197682 Italian.
-
Significance of capillary basement membrane changes in diabetes mellitus.J Am Podiatr Med Assoc. 1990 Jun;80(6):307-13. doi: 10.7547/87507315-80-6-307. J Am Podiatr Med Assoc. 1990. PMID: 2189988 Review.
Cited by
-
Basement membrane.J Clin Pathol Suppl (R Coll Pathol). 1978;12:59-66. J Clin Pathol Suppl (R Coll Pathol). 1978. PMID: 365894 Free PMC article. Review. No abstract available.
-
Mechanical and chemical properties of the skin and its collagen from lean and obese-hyperglycaemic (ob/ob) mice.Diabetologia. 1984 Jul;27(1):44-9. doi: 10.1007/BF00253500. Diabetologia. 1984. PMID: 6468798
-
Molecular form and concentration of serum α2-macroglobulin in diabetes.Sci Rep. 2019 Sep 10;9(1):12927. doi: 10.1038/s41598-019-49144-7. Sci Rep. 2019. PMID: 31506491 Free PMC article.
-
Salivary proteins associated with hyperglycemia in diabetes: a proteomic analysis.Mol Biosyst. 2013 Nov;9(11):2785-97. doi: 10.1039/c3mb70196d. Mol Biosyst. 2013. PMID: 24056972 Free PMC article.
-
Serum alpha 2-macroglobulin levels in diabetes.J Clin Pathol. 1980 Feb;33(2):163-6. doi: 10.1136/jcp.33.2.163. J Clin Pathol. 1980. PMID: 6154066 Free PMC article.