Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1968 Jun;3(5):447-55.

The relationship of desoxyribonuclease inhibitor levels in human sera to the occurrence of antinuclear antibodies

P G Frost, P J Lachmann

The relationship of desoxyribonuclease inhibitor levels in human sera to the occurrence of antinuclear antibodies

P G Frost et al. Clin Exp Immunol. 1968 Jun.

Abstract

A group of sera from hospital patients and normal subjects has been tested for the presence of antinuclear antibodies, and the amount of labile inhibitor to desoxyribonuclease 1 present in each of the sera estimated. It has been found that the presence of antinuclear antibodies is associated with a high level of inhibitor to a statistically significant degree.

It has also been found that this inhibitor is formed during the clotting of whole blood and that it is derived from platelets. A possible relationship between the inhibitor, its formation during the clotting of blood, and the characteristic presence of antinuclear antibodies in systemic lupus erythematosus is discussed.

PubMed Disclaimer

References

    1. Cancer Res. 1952 May;12(5):341-5 - PubMed
    1. J Clin Invest. 1953 Mar;32(3):193-201 - PubMed
    1. J Clin Invest. 1954 Dec;33(12):1670-86 - PubMed
    1. J Physiol. 1955 Apr 28;128(1):9-27 - PubMed
    1. Arch Biochem Biophys. 1963 Apr;101:88-95 - PubMed

LinkOut - more resources