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. 1968 Jul;15(1):35-50.

Strain differences in the immune response of mice. I. The neonatal response to sheep red cells

J H Playfair

Strain differences in the immune response of mice. I. The neonatal response to sheep red cells

J H Playfair. Immunology. 1968 Jul.

Abstract

Neonatal mice of the inbred strains NZB, Balb/c and C57B1 were injected with sheep, pig or chicken red cells at various ages and antibody plaque-forming cell (PFC) responses in their spleens measured.

Marked strain differences were found, notably a high early response by NZB mice to sheep cells. Hybrid and backcross experiments suggested that this was genetically controlled by at least three genes. C57B1 mice were late in developing a response to all of the antigens tested.

The kinetics of the PFC responses were interpreted as favouring an explanation not involving cell division in response to antigen.

Thymectomy at birth reduced the PFC responses in 1-month-old mice of all three strains to the same low level, while thymectomy after 7 days left the PFC responses intact. It is argued that the thymus must be present for strain-specific immune responses to develop.

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