Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Jul 21;201(4352):262-4.
doi: 10.1126/science.566469.

Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food

R A Wise, J Spindler, H deWit, G J Gerberg

Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food

R A Wise et al. Science. .

Abstract

The dopamine receptor blocker pimozide attenuated lever-pressing and running for food reward in hungry rats. In each case the characteristic behavior of pimozide-treated rats was the same as that of undrugged rats when reward was simply withheld. Drug-induced performance difficulties were ruled out by the presence of periods of normal responding in drug-treated animals. Pimozide appears to selectively blunt the rewarding impact of food and other hedonic stimuli.

PubMed Disclaimer

LinkOut - more resources