Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Nov;54(2):423-6.
doi: 10.1530/jrf.0.0540423.

Maternal age and the incidence of aneuploidy in first-cleavage mouse embryos

I Maudlin, L R Fraser

Maternal age and the incidence of aneuploidy in first-cleavage mouse embryos

I Maudlin et al. J Reprod Fertil. 1978 Nov.

Abstract

Eggs obtained from young virgin and aged parous female mice were fertilized in vitro to compare the incidence of aneuploidy in the resulting first-cleavage embryos. There was a significantly higher incidence of aneuploidy in the aged group (7.5% versus 3.3%) and this was due solely to a higher proportion of trisomic female chromosome complements; there was no difference in the incidence of monosomics. These results thus suggest that non-disjunction occurs more frequently in eggs from older females, leading to the production of aneuploid embryos.

PubMed Disclaimer