The influence of high ambient temperature on thermoregulatory response to intrahypothalamic injections of noradrenaline and serotonin in the pigeon

Abstract

1. Pigeons with chronically implanted injection cannula in the hypothalamus were injected with noradrenaline (NA, 10 micrograms/microliter) and 5-hydroxytryptamine (5-HT, 10 micrograms/microliter) at the ambient temperature (Ta) of 38 degrees or 42 degrees C. 2. Initial tests at cold (6 degrees C) indicated that birds responded hypothermically to NA and in most instances also to 5-HT. 3. Intrahypothalamic injection of NA (10 micrograms/microliter) had no appreciable effect on oxygen consumption (VO2), body temperature (Tb), foot temperature (Tf), or heart and respiratory rates at Ta 38 degrees C. The increase of VO2, Tb and Tf noted after similar injection at 42 degrees C was in all probability due to observed excitement and bursts of struggling rather than effects on thermoregulatory mechanisms. 4. 5-HT (10 micrograms/microliter) injected at Ta 38 degrees C depressed respiratory frequency from panting (600 breaths.min-1) to normal rate (ca. 50.min-1) within 2--4 min. The absence of panting lasted about 10 min, but only a slight increase of VO2, Tb and Tf followed. At Ta 42 degrees C, no notable changes of VO2, Tb and Tf were recorded after 5-HT injection. 5. It is concluded that 5-HT has an inhibitory action on neuronal pathway controlling panting activity in the pigeon, but NA seems to be ineffective.