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. 1978 Oct 18;377(1):57-63.
doi: 10.1007/BF00584374.

Effect of divalent cations on acetylcholine release from cardiac parasympathetic nerve endings

H G Glitsch, L Pott

Effect of divalent cations on acetylcholine release from cardiac parasympathetic nerve endings

H G Glitsch et al. Pflugers Arch. .

Abstract

The influence of several divalent cations on acetylcholine (ACh) release from vagus nerve terminals was studied in quiescent guinea-pig auricles. ACh release was induced by stimulus trains subthreshold for excitation of atrial cells. The ACh released evoked a hyperpolarization of the atrial cell membrane. Changes in ACh sensitivity of the atrial cell membrane were tested by application of ACh-containing solutions. ACh release increased with the external Ca concentration. External Sr maintained the ACh release in 'Ca-free' media. However, Sr ions were less effective than Ca ions. External Mg acted as a weak inhibitor of the stimulus evoked ACh release, whereas Co and Mn ions exerted a strong inhibition.

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