Changes in the effects of cocaine during chronic treatment
- PMID: 569350
Item in Clipboard
Changes in the effects of cocaine during chronic treatment
Res Commun Chem Pathol Pharmacol.
1978 Oct.
Abstract
The principle object of the study was to identify the changes in the rat's response to cocaine which occurred during chronic administration of the drug. Doses of 20 and 35 mg/Kg cocaine were administered at intervals of 12 and 24 hours, for 300 days or until their effects proved fatal. Four main effects were observed: sensitization to cocaine's convulsant and behavioral activating properties, tolerance to its weight loss effects and decreased response duration. Convulsant sensitization occurred primarily among rats receiving the higher dose of cocaine. All other effects occurred with equal frequency in rats at both doses. None of the changes were dependent on the interval between injections.
Similar articles
-
[An ontogenic study of behavioral sensitization to cocaine in the rat].Nihon Shinkei Seishin Yakurigaku Zasshi. 1994 Feb;14(1):39-45. Nihon Shinkei Seishin Yakurigaku Zasshi. 1994. PMID: 8048281 Japanese.
-
Time course of the development of behavioral sensitization and dopamine receptor up-regulation during binge cocaine administration.J Pharmacol Exp Ther. 1994 Sep;270(3):1387-96. J Pharmacol Exp Ther. 1994. PMID: 7932193
-
Cocaine sensitization in periadolescent and adult rats.J Pharmacol Exp Ther. 1995 Oct;275(1):345-57. J Pharmacol Exp Ther. 1995. PMID: 7562570
-
State-dependent action of cocaine on brain temperature and movement activity: implications for movement sensitization.Pharmacol Biochem Behav. 2004 Apr;77(4):823-37. doi: 10.1016/j.pbb.2004.02.009. Pharmacol Biochem Behav. 2004. PMID: 15099929
-
Chronic intracerebroventricular administration of recombinant CART(42-89) peptide inhibits and causes weight loss in lean and obese Zucker (fa/fa) rats.Obes Res. 2000 Nov;8(8):590-6. doi: 10.1038/oby.2000.76. Obes Res. 2000. PMID: 11156435
Cited by
-
Effects of adolescent exposure to cocaine on locomotor activity and extracellular dopamine and glutamate levels in nucleus accumbens of DBA/2J mice.Brain Res. 2008 Feb 8;1193:34-42. doi: 10.1016/j.brainres.2007.11.045. Epub 2007 Dec 5. Brain Res. 2008. PMID: 18178178 Free PMC article.