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. 1968 Dec 6;162(3858):1132-4.
doi: 10.1126/science.162.3858.1132.

Erythropoiesis in the rat: differential rates of DNA synthesis and cell proliferation

F C Monette, J LoBue, A S Gordon, P Alexander Jr, P C Chan

Erythropoiesis in the rat: differential rates of DNA synthesis and cell proliferation

F C Monette et al. Science. .

Abstract

Direct in vivo estimates of DNA synthesis time in early and late erythroblasts were obtained by using the H(3)- and C(14)-thymidine double-la-beling technique. A double-emulsion autoradiographic procedure was used to resolve the two isotopes. Early erythroblasts were found to proliferate at a rate about five times that of late cells. This results primarily from a shorter mean DNA synthesis time in early cells (2.5 hours) than in late cells (6.5 hours).

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