Mice unilaterally sensitized for audiogenic seizures

Abstract

Strain SJL/J mice exposed to loud bell-ringing (primed) with one ear blocked do not convulse, but are susceptible to audiogenic seizures 48 hours later when stimulated only through the ear open at priming. Mice stimulated through the ear blocked at priming do not convulse, but are convulsible when retested on the opposite ear. The site of sensitization appears to be either in the ear or in those portions of the auditory system receiving input only from one side.