Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1968 Nov 1;162(3853):574-6.
doi: 10.1126/science.162.3853.574.

Immunoglobulin M antibodies with ten combining sites

K Onoue, A L Grossberg, Y Yagi, D Pressman

Immunoglobulin M antibodies with ten combining sites

K Onoue et al. Science. .

Abstract

Immunoglobulin M rabbit antibodies to a hapten are shown to have ten binding sites per molecule. The affinity for the specific hapten is approximately 100 times greater for one-half of the sites than for the other half. All sites are retained in the five 7S subunits produced by reduction and alkylation of the immunoglobulin M. Each of the 7S subunits of the IgM molecule apparently has one strong and one weak site.

PubMed Disclaimer

LinkOut - more resources