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. 1979 Jan 15;178(1):245-8.
doi: 10.1042/bj1780245.

Involvement of cytoskeletal structures in nerve-growth-factor-mediated induction of ornithine decarboxylase

J Lakshmanan

Involvement of cytoskeletal structures in nerve-growth-factor-mediated induction of ornithine decarboxylase

J Lakshmanan. Biochem J. .

Abstract

Induction of ornithine decarboxylase elicited in response to nerve-growth factor in target organs is greatly decreased by preincubation of these tissues with cytoskeletal poisons such as vinblastine, diamide, cytochalasin B and colchicine. These results are interpreted as evidence for the involvement of receptor-associated cytoskeletal structures in mediating the nerve-growth-factor-specific induction of ornithine decarboxylase.

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