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. 1968 Oct;2(10):962-5.
doi: 10.1128/JVI.2.10.962-965.1968.

Viral events necessary for the induction of interferon in chick embryo cells

R Z Lockart Jr, N L Bayliss, S T Toy, F H Yin

Viral events necessary for the induction of interferon in chick embryo cells

R Z Lockart Jr et al. J Virol. 1968 Oct.

Abstract

Temperature-sensitive mutants of Sindbis virus were employed to investigate the nature of the viral event(s) which induces chick-embryo cells to produce interferon. Chick embryo cells induced by the parental heat-resistant strain of Sindbis virus produced essentially equal amounts of interferon at 29 and 42 C. An RNA(-) and three RNA(+) strains [temperature-sensitive mutants unable (RNA(-)) and able (RNA(+)) to make ribonucleic acid] produced interferon at 29 C but not at 42 C. It is concluded that viral RNA per se and the replication of viral RNA do not induce interferon production by chick embryo cells.

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References

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