doi: 10.1007/BF00234841.
Effects of halothane on microtubules in the sciatic nerve of the rat
- PMID: 573178
- DOI: 10.1007/BF00234841
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Effects of halothane on microtubules in the sciatic nerve of the rat
Cell Tissue Res.
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Abstract
The effect of halothane and colchicine on microtubule repolymerisation after exposure to cold has been examined in the sciatic nerve of the rat. Myelinated axons showed a significant decrease in microtubule numbers and density after exposure to both 20 mM halothane and 10(-5) M colchicine; exposure to both agents simultaneously produced a further significant reduction when compared to halothane alone. It is suggested that halothane can interfere with microtubule repolymerisation in mammalian axons possibly in a similar way to that described in invertebrates.
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