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Comparative Study
. 1979 Jul;381(1):75-7.
doi: 10.1007/BF00582335.

The role of intrinsic, non-adrenergic, non-cholinergic inhibitory nerves in the regulation of distensibility of the guinea-pig colon

J S Davison, G T Pearson
Comparative Study

The role of intrinsic, non-adrenergic, non-cholinergic inhibitory nerves in the regulation of distensibility of the guinea-pig colon

J S Davison et al. Pflugers Arch. 1979 Jul.

Abstract

1. The lengthening responses of segments of distal colon of guinea-pigs to applied weights were measured. 2. Distensibility was reduced by tetrodotoxin and quinidine; increased by atropine and hyoscine, and unaffected by guanethidine and phentolamine. 3. Tension changes produced by controlled stretches were increased by tetrodotoxin. 4. These results suggest that there is a net, inhibitory, non-adrenergic, non-cholinergic influence acting on the muscle during stretch against a background of cholinergic excitatory tone. This inhibitory activity may be activated reflexly by stretch.

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References

    1. J Exp Zool. 1975 Oct;194(1):103-33 - PubMed
    1. J Physiol. 1969 Dec;205(3):549-62 - PubMed
    1. Br J Pharmacol. 1970 Dec;40(4):668-88 - PubMed
    1. Clin Exp Pharmacol Physiol. 1977 Jan-Feb;4(1):37-41 - PubMed

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