Determination of the role of serotonergic and cholinergic systems in apomorphine--induced aggressiveness in rats
- PMID: 573894
Determination of the role of serotonergic and cholinergic systems in apomorphine--induced aggressiveness in rats
Abstract
Aggressive behavior was produced in rats by administration of apomorphine (APO) 20 mg/kg ip. Serotonin (5-HT) agonists, L-tryptophan or 5-hydroxytryptophan and a MAO inhibitor, pargyline, suppressed the APO-induced aggressiveness. However, cyproheptadine was the only one of four 5-HT antagonists used which potentiated the aggressive behavior. Cyproheptadine, metergoline and PCPA released aggressiveness in rats pretreated with a subthreshold dose of APO. Cholinomimetics (pilocarpine, oxytremorine and physostigmine) completely blocked APO induced aggressiveness while cholinolytics (atropine and scopolamine) partially suppressed the inhibiting effect of pilocarpine on aggressive behavior. The results obtained suggest the existence of an interaction between serotonergic, cholinergic systems and dopaminergic system in apomorphine-induced aggressiveness in rats.
Similar articles
-
The role of serotonergic and cholinergic systems in the aggression-stereotypy complex produced by amphetamine in mice.Pol J Pharmacol Pharm. 1977 Nov-Dec;29(6):591-602. Pol J Pharmacol Pharm. 1977. PMID: 304574
-
[Analysis of apomorphine aggessiveness and stereotypy: role of serotonin- and cholinergic systems of the brain].Zh Vyssh Nerv Deiat Im I P Pavlova. 1977 Nov-Dec;27(6):1303-7. Zh Vyssh Nerv Deiat Im I P Pavlova. 1977. PMID: 145765 Russian.
-
Serotonergic modulation of footshock induced aggression in paired rats.Indian J Exp Biol. 1991 Jul;29(7):631-5. Indian J Exp Biol. 1991. PMID: 1839019
-
5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis.Eur J Pharmacol. 2005 Dec 5;526(1-3):125-39. doi: 10.1016/j.ejphar.2005.09.065. Epub 2005 Nov 28. Eur J Pharmacol. 2005. PMID: 16310183 Review.
-
From genes to aggressive behavior: the role of serotonergic system.Bioessays. 2006 May;28(5):495-503. doi: 10.1002/bies.20412. Bioessays. 2006. PMID: 16615082 Review.
Cited by
-
Induction of aberrant agonistic behavior by a combination of serotonergic and dopaminergic manipulation in rats.Brain Struct Funct. 2021 May;226(4):1253-1267. doi: 10.1007/s00429-021-02238-3. Epub 2021 Feb 24. Brain Struct Funct. 2021. PMID: 33625560
-
The effect of increased serotonergic neurotransmission on aggression: a critical meta-analytical review of preclinical studies.Psychopharmacology (Berl). 2009 Aug;205(3):349-68. doi: 10.1007/s00213-009-1543-2. Epub 2009 Apr 30. Psychopharmacology (Berl). 2009. PMID: 19404614 Review.