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. 1979 Sep;31(5):634-41.

Human male infertility, probably genetically determined, due to defective meiosis and spermatogenic arrest

R S Chaganti, J German

Human male infertility, probably genetically determined, due to defective meiosis and spermatogenic arrest

R S Chaganti et al. Am J Hum Genet. 1979 Sep.

Abstract

A family is reported in which infertility affected three men related through their mothers. The propositus, from testicular tissue was obtained, exhibited desynapsis, lack of chiasmata, and degeneration of spermatocytes during the first meiotic division. These observations lead us to postulate that a gene for meiotic disturbance, spermatogenic arrest, and azoospermia is segregating in this family; its mode of inheritance conforms to either an X-linked recessive or a sex-limited autosomal dominant transmission.

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References

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