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. 1968 Nov;2(11):1326-38.
doi: 10.1128/JVI.2.11.1326-1338.1968.

Cytoplasmic structures associated with an arbovirus infection: loci of viral ribonucleic acid synthesis

P M Grimley, I K Berezesky, R M Friedman

Cytoplasmic structures associated with an arbovirus infection: loci of viral ribonucleic acid synthesis

P M Grimley et al. J Virol. 1968 Nov.

Abstract

Unique cytoplasmic structures, herein designated as type I cytopathic vacuoles (CPV-I), are found in chick embryo cells early in the logarithmic phase of Semliki Forest virus replication. High resolution autoradiography demonstrated that the CPV-I are loci of (3)H-uridine incorporation. This evidence correlates well with previous biochemical data and electron microscopy of the subcellular fractions active in Semliki Forest virus ribonucleic acid synthesis. Origin of the CPV-I within host cell cytoplasm is confirmed by the distribution of electron-dense tracer particles and sequential ultrastructural observations.

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